Current Issue : April-June Volume : 2015 Issue Number : 2 Articles : 4 Articles
In the present study attempts were made to formulate 35 mg Trimetazidine Dihydrochloride Sustained release matrix tablet which can deliver drug at a near constant rate for 8 hours. Sustained release matrix tablets of Trimetazidine Dihydrochloride were prepared by Wet granulation method. Initially tablets were prepared with drug to polymer with HPMC in formulation F1 released 98.33% of drug within 4 hrs. Polymer concentration was increased in the further trials of F2 released, 84.40% in 6 hours. Polymer concentration was again increased in other trial of F3 released, 103.66% in 6 hours. In Formulation F4, the polymer HPMC concentration was increased released 95.50% in 8 hours. Tablets were prepared with different concentration of the polymer. The drug released from formulation of F1, F2, F3 and F4 were 98.33%, 84.40%, 103.66% and 95.50% in 4, 4, 6 and 8 hours respectively. Batch F4 was found to obey higuchi release kinetic model. Compatibility study was carried out for drug polymer interaction, revealed that there is no interaction of the polymer with the drug....
Fungal infection of the skin is one of the most common problems faced with dermatological diseases in worldwide. Topical therapy is a most suitable choice for the treatment of the cutaneous infections. Azoles are the most commonly used antifungals in the clinical treatment of local and systemic fungal infections. Topical therapy for fungal infection is advantageous because the drugs are targeting to the site of infection and reduces the risk of systemic side effects. Formulation design and optimization are key steps for increasing the therapeutic efficacy. Recently, the fungal infection of the skin the antifungal drugs generally used as conventional cream and gel preparation for the treatment. The effectiveness of that treatment is mainly depends on the permeation of drugs through the targeting layer of skin. The stratum corneum of the skin acts as a principle barrier to the permeation of topically applied drugs. The physiochemical properties of drug molecule and formulation type are most useful factors in topical drug delivery system. Therefore, a number of new advances in formulation have been investigated for delivering antifungal drugs through skin target site. This review focuses on recent advances in topical formulation approaches to improve the penetration of antifungal drugs through skin....
To formulate and evaluate Scopolamine in situ nasal gel using polymers.Scopolamine was first extracted from Datura metel, Solanaceae family. Extracted Scopolamine was investigated by different Pharmacognostical parameters. Scopolamine was used to prepare nasal in situ gel using polymers like Carbopol 934P and Sodium alginate. Formulated Scopolamine nasal in situ gel was evaluated by various Pharmaceutical parameters. The stability study of finished Scopolamine in situ nasal gel was done as per ICH guidelines. All the evaluation parameters or raw materials and finished product were found to be under specified limit. Scopolamine nasal in situ gel was evaluated by standardize procedure. The results of various quality control measures like Moisture content, Determination of ash; Total ash, Acid insoluble ash, water soluble ash, Alcohol soluble extractive, Water soluble extractive, Foreign matter comes under the specified limit. All ingredients used in the formulation and finish products possessed good quality and Purity. Scopolamine nasal in situ gel possess significant antimuscarinic, anesthetics, mydriatic activities and can be used safely for motion sickness....
Graphene oxide [GO] nanocomposites have rapidly grown as a new type of nanomaterial. This paper provides a comprehensive review of the present trends in graphene oxide research with an emphasis on graphene based nanocomposites. Various synthesis methods have recently been devised for production of graphene oxide nanocomposites. Graphene oxide, a two dimensional nanomaterial has been widely investigated for its novel physicochemical properties and potential application due to their small size, large surface area and ability to interact with cell or tissues. Graphene oxide has unique structure and excellent mechanical, optical, electrical properties and has been exploited in electronics and other fields. This review also elaborates recent development of nanocomposites as a platform in novel drug delivery system....
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